Studies on semi-synthetic 7.ALPHA.-formamidocephalosporins. II Synthesis and antibacterial activity of some 7.ALPHA.-formamidoceph-3-em-1-oxide and 7.ALPHA.-formamido-1-oxadethiaceph-3-em derivatives.
نویسندگان
چکیده
منابع مشابه
STUDIES ON SEMI-SYNTHETIC 7a-FORMAMIDOCEPHALOSPORINS III. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME
l -yl)carbonylamino]acetamido]-7a:-formamidocephalosporins with various substituents at the C-3 position of the cephalosporin nucleus is described. Inhibition of Gram-positive and Gram-negative bacteria including /Mactamase producing strains was observed with phenyl as the aryl residue. The 3,4-dihydroxyphenyl group further enhanced the activity against Gram-negative organisms; in this series, ...
متن کاملBiotransformation of pregnenolone - 7alpha-3H, progesterone - 7alpha-3H and dehydroepiandrosterone - 7alpha-3H by porcine fetal and maternal adrenal homogenate preparations.
The biotransformation of pregnenolone-7alpha-3H and of progesterone-7alpha-3H by porcine fetal and maternal adrenal homogenates at 56 and 112 days of pregnancy and of dehydroepiandrosterone-7alpha-3H by fetal adrenal homogenates has been investigated in vitro. Both pregnenolone-7alpha-3H and progesterone-7alpha-3H were metabolized extensively by maternal adrenal preparations, the principal radi...
متن کاملSynthesis of chimeric 7alpha-substituted estradiol derivatives linked to cholesterol and cholesterylamine.
We report the synthesis of 7alpha-substituted beta-estradiol derivatives bearing side chains terminated with cholesterol and 3beta-cholesterylamine. These chimeric compounds were designed to exhibit high affinity for estrogen receptors (ERs) and cellular plasma membranes to potentially enable regulated uptake of ERs by mammalian cells. Evaluation with recombinant yeast reporting compound-mediat...
متن کاملDetermination of hepatic cholesterol 7alpha-hydroxylase activity in man.
Methods were developed to determine the activity of the microsomal enzyme cholesterol 7alpha-hydroxylase in human liver. The enzyme assay could be performed with as little as 20 mg of fresh liver tissue, thus making the procedure applicable to specimens obtained by percutaneous liver biopsy. Optimal assay conditions were determined and the identity and radioactive purity of the reaction product...
متن کاملEvaluation of Antibacterial and Antifungal Activity of some 1, 3, 4 Oxadiazoles
In the last three decades investigations in the field of oxadiazoles have been intensified due to their diverse therapeutic uses. Oxadiazole are well known to have a wide range of therapeutic activities namely anti-inflammatory, analgesic, antipyretic, anticonvulsant, antiparasitic, antimicrobial etc. In this study, we have evaluated the antimicrobial activity of some carboxymethyl derivativ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1986
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.39.1792